Table 1.

Physical constants used in the CFD models to describe the mass transport of oxygen and a small molecule test compound in each bioreactor.

Parameter name	Value	Reference
$D_{{\text{O}}_{\text{2}}}$, O2 diffusion coefficient in aqueous media	3 × 10−9 m2/s	Mazzei et al. (2010) and Buchwald (2011)
Cell-normalized O2 consumption rate in hepatocytes	0.4 nmol/s/106 cells	Balis et al. (1999)
km, Michaelis–Menten constant	5.6 mmHg	Foy et al. (1994) and Allen and Bhatia (2003)
ccr, critical O2 concentration	2.82 × 10−3 mol/m3	De Groot et al. (1988)
C0, O2 concentration at inlet	0.214 mol/m3	Mazzei et al. (2010)
$K_{{\text{O}}_{\text{2}}}$, Henry’s law constant	932.4 atm/mol/L	Mazzei et al. (2010)
Dtest, test compound diffusion coefficient	1 × 10−8 m2/s	Estimated
O2 solubility	0.2 mol/m3	USGS (2016)