Figure 7.

Model of ADAP actions in neurons. In hippocampal neurons ADAP exists in a complex with SKAP-HOM, RAPL and MST1. ADAP stimulates the “inside out” activation of β1 integrins on the dendrites of these neurons and enhances dendritic growth in primary hippocampal culture. Modulation of NF-κB activity and MAP2 expression through ADAP may also contribute to the dendritic development, but require further investigation as they could not be rescued through the reconstitution of ADAP expression in our experiments.