Table 3.
Haematological analysis of SNE (100, 300 and 1000 mgkg−1) after a 90-day observation period
| Parameter | Vehicle | SNE 100mgkg−1 | SNE 300mgkg−1 | SNE 1000mgkg−1 | P value |
| WBC (103 µL−1) | 6.50± 0.73 | 2.42 ± 0.52** | 5.92 ± 1.02 | 6.50 ± 0.25 | 0.03 |
| RBC (106 µL−1) | 7.34 ± 0.24 | 7.90 ± 0.15 | 7.80 ± 0.18 | 8.05 ± 0.20 | 0.10 |
| HGB (g dL−1) | 13.50 ± 0.37 | 12.06 ± 2.27 | 14.04 ± 0.37 | 14.48 ± 0.08 | 0.56 |
| HCT (%) | 42.56± 1.10 | 45.00 ± 1.34 | 44.26 ± 1.36 | 46.30 ± 0.56 | 0.21 |
| MCV (fl) | 58.08± 0.58 | 57.90 ± 0.68 | 56.66 ± 0.5 | 57.53 ± 0.72 | 0.38 |
| MCH (pg) | 18.42 ± 0.18 | 15.52 ± 2.88 | 18.00 ± 0.16 | 18.03 ± 0.48 | 0.53 |
| MCHC (gdL−1) | 31.68 ± 0.16 | 26.62 ± 4.86 | 31.76 ± 0.29 | 31.28± 0.45 | 0.43 |
| PLT (103 µL−1) | 792.4 ± 19.88 | 523.0 ± 188.50 | 729.0 ± 100.80 | 756.50±114.90 | 0.38 |
| LYM (%) | 82.52 ± 1.48 | 68.34 ± 17.25 | 76.14 ± 5.05 | 80.28 ± 2.94 | 0.73 |
| NEUT (%) | 14.04 ± 1.25 | 26.64 ± 15.73 | 19.14 ± 3.96 | 15.45 ± 2.00 | 0.73 |
| LYM# (103 µL−1) | 5.36 ± 0.67 | 2.63 ± 0.49 | 4.64 ± 0.97 | 5.25 ± 0.40 | 0.13 |
| NEUT# (103 µL−1) | 0.94 ± 0.09 | 0.42 ± 0.13* | 1.00 ± 0.17 | 0.98± 0.11 | 0.02 |
| RDW_SD (fl) | 30.00 ± 0.28 | 30.22 ± 0.66 | 29.88 ± 0.41 | 29.80 ± 0.39 | 0.93 |
| RDW_CV (%) | 11.50 ± 0.23 | 11.86 ± 0.37 | 11.82 ± 0.18 | 12.15 ± 0.55 | 0.63 |
| PDW (fl) | 7.88 ± 0.16 | 9.47 ± 1.42 | 7.82 ± 0.14 | 7.90 ± 0.27 | 0.16 |
| MPV (fl) | 6.76 ± 0.09 | 7.23 ± 0.48 | 6.22 ±0.10 | 6.87 ±0.18 | 0.27 |
| P_LCR (%) | 4.94 ± 0.55 | 8.37 ± 3.23 | 4.36 ±0.43 | 5.80 ±0.81 | 0.20 |