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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Toxicol Appl Pharmacol. 2014 Dec 9;282(3):252–258. doi: 10.1016/j.taap.2014.11.017

Fig. 6.

Fig. 6

DDR proteins are generally increased in response to PM exposure. Total protein was isolated from SIGCs treated with DMSO or PM (3 or 6 μM) for (A) 24 h or (B) 48 h, followed by Western blotting (n = 3 per treatment/timepoint). All treatments were run on the same gel per timepoint (n = 3/treatment) as depicted in the blots presented. Ponceau S was used for normalization with protein of interest and values were reported as raw mean value ± SEM. Different letters indicate differences between treatments; P < 0.05. PM induced increased γH2AX, ATM, PARP-1, PRKDC, XRCC6, BRCA1, and RAD51 after 24 h of the 6 μM PM exposure, while the 3 μM PM exposure increased γH2AX, ATM, PARP-1, PRKDC, and BRCA1 after 48 h.