TABLE 2.
TG reactivation detected by explant cultures in mice infected with different doses of LAT(+) and LAT(−) virusesa
| Virus | No. (%) of TG showing virus/total TG by doseb (PFU/eye) |
|||||
|---|---|---|---|---|---|---|
| 2 × 105 | 1 × 105 | 2 × 104 | 1 × 104 | 2 × 103 | 1 × 103 | |
| McKrae [LAT(+)] | 34/34 (100) | 18/20 (90) | 13/16 (80) | 10/20 (50) | 0/16 (0) | 0/10 (0) |
| dLAT2903 [LAT(−)] | 23/23 (100) | 15/20 (75) | 7/12 (60) | 9/20 (45) | 0/12 (0) | 0/10 (0) |
| KOS [LAT(+)] | 10/20 (50) | ND | ND | ND | ND | ND |
| RE [LAT(+)] | 18/20 (90) | ND | ND | ND | ND | ND |
a
TG from latently infected mice were isolated on day 28 p.i., and the presence of infectious virus for each TG culture was monitored daily for up to 15 days postculture as described in Materials and Methods.
b
Numbers for each virus indicate the number of TG showing CPE per total number of tested TG. Numbers in parentheses indicate the percentage of TG that showed CPE. ND, not done.