FIG 3.

Timelines for participants 1010, 2004, 5095, 6083, 4175, and 4154. The timelines highlight major clinical evaluations, procedures, and pathologies diagnosed during the course of each NNAB-participant's HIV infection. Some VL and CD4⁺ cell measurements are noted (additional measurements are available at the NNAB for each participant). Time “0” indicates the year of HIV diagnoses, with tick marks indicating subsequent years extending until the participant's death. A symbol legend is shown at the bottom of Fig. 5. Abbreviations: VL, viral load (copies per cubic millimeter); CD4⁺, CD4⁺ counts (cells per cubic millimeter); UD, undetectable (using the limits available at the time of testing); HSV, herpes simplex virus; HPV, human papillomavirus; Chemo, chemotherapy; CMV, cytomegalovirus; GI, gastrointestinal; HAND, HIV-associated neurocognitive disorders, which encompass ANI (asymptomatic neurocognitive disorder), MND (minor neurocognitive disorder, similar to minor cognitive motor disorder [MCMD]), and HIV-associated dementia (HAD); PCP, Pneumocystis jirovecii pneumonia; PEL, primary effusion lymphoma; IRIS-KS, immune reconstitution inflammatory syndrome complicating Kaposi's sarcoma; HCV, hepatitis C virus; COPD, chronic obstructive pulmonary disease.