TABLE 2.

Magnitude and sense of fitness differences between mutant and parental genotypes

Host genotype	Virus genotype	Wma	Wpb	Wm − Wp	Pc
L+/L+	TS-(M138N)	0.967	0.961	0.006	0.552
L+/L+	TS-(T43K+D50G)	0.931	0.961	−0.030	0.002*
L+/L+	TS-(L13F+G66V)	0.902	0.961	−0.059	0.000*
L+/L+	MG-(M138N)	0.908	0.918	−0.010	0.367
L+/L+	MG-(A87G)	0.890	0.918	−0.028	0.010*
L1/L1	TS-(M138N)	0.918	0.899	0.019	0.007*
L1/L1	TS-(T43K+D50G)	0.886	0.899	−0.013	0.068
L1/L1	TS-(L13F+G66V)	0.884	0.899	−0.015	0.040*
L1/L1	MG-(M138N)	0.937	0.921	0.016	0.025*
L1/L1	MG-(A87G)	0.891	0.921	−0.030	<10−3*
L2/L2	TS-(M138N)	0.820	0.832	−0.012	0.505
L2/L2	TS-(T43K+D50G)	0.867	0.832	0.035	0.048*
L2/L2	TS-(L13F+G66V)	0.847	0.832	0.015	0.393
L2/L2	MG-(M138N)	0.905	0.910	−0.005	0.773
L2/L2	MG-(A87G)	0.900	0.910	−0.010	0.577

^aW_m is the average fitness of each mutant in each host at 22 dpi.

^bW_p is the average fitness of each parental genotype.

^cThe asterisk indicates significance at a P value of ≤0.05 for fitness differences according to an LSD analysis.