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. 2016 Sep 29;90(20):9338–9349. doi: 10.1128/JVI.01503-16

FIG 4.

FIG 4

Representative images of ERVK reverse transcriptase (RT) in cortical brain tissue. Representative images show ERVK RT expression (green) in prefrontal cortex autopsy tissues (Brodmann area 9; NIH NeuroBioBank) from an individual with cancer (neuronormal; individual 3371) and a patient with ALS (individual 5215). Five total tissues were examined for each clinical group. (Left) Mosaic tiling (magnification, ×10) reveals enhanced ERVK RT expression in deep cortical tissue (cortical layer V) and upper cortical tissue (cortical layer III) in an ALS specimen. (Right) Nissl-stained cells reveal ERVK RT staining mainly in large pyramidal neurons. Nuclear DAPI staining is shown in blue. Bars, 10 μm for middle and right panels.