Chemical structures of acylguanidine compounds, namely, 5-(N,N-hexamethylene)amiloride (HMA) (A), N-(5-(1-methyl-1H-pyrazol-4-yl)naphthalene-2-carbonyl)guanidine (BIT-225) (B), 1-(2-(azepan-1-yl)nicotinoyl)guanidine (SM111) (C), and C-(6-azepan-1-yl-pyridin-3-yl)-methylamine (SM113) (D).