FIG 4.
SM111 inhibits in vitro replication of antiretroviral-resistant HIV-1 strains in CEM-GXR cells. (A) Properties of drug-resistant viruses, including primary mutations and representative antiretroviral drugs. (B) Replication of HIV-1NL4.3 in the absence or presence of 100 nM antiretroviral drugs or 100 μM SM111. (C) Replication of HIV-1PI-RS in the absence or presence of 100 nM indinavir or 100 μM SM111. (D) Replication of HIV-1NRTI-RS in the absence or presence of 100 nM azidothymidine or 100 μM SM111. (E) Replication of HIV-1NNRTI-RS in the absence or presence 100 nM efavirenz or 100 μM SM111. (F) Replication of HIV-1INI-RS in the absence or presence 100 nM raltegravir or 100 μM SM111. For panels B to F, error bars represent means ± SD. Data are representative of two independent experiments performed in triplicate.