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SM111 selects for mutations in Vpu and Env. Culture of HIV-1NL4.3 in CEM-GXR cells in the presence of 100 μM SM111 is shown. Strains A to N represent 14 independent infected cultures. Viral outgrowth was observed in 2 of 14 (14.3%) cultures (strains C and H) by day 9. Mutations identified in each strain by full-genome viral sequencing are annotated.
