TABLE 1.
Comparison of entry receptor usages of B virus, HSV-1, and HSV-2
| Virus | Titer (PFU/ml) on cells |
Titer relative to Vero cell infectivity (%)a |
||||||
|---|---|---|---|---|---|---|---|---|
| Vero | B78-HVEM | B78-nectin-1 | B78-nectin-2 | B78c | B78-HVEM | B78-nectin-1 | B78-nectin-2 | |
| B virus E2490 | 7.5 × 107 | 0 | 3.0 × 106 | 1.3 × 106 | 0 | 0.0 | 4.0 | 1.7 |
| HSV-1 (KOS) | 1.8 × 108 | 1.5 × 107 | 8.2 × 106 | 0 | 0 | 8.3 | 4.5 | 0.0 |
| HSV-2 (G) | 1.3 × 107 | 9.5 × 106 | 3.0 × 106 | 1.0 × 103 | 1.0 × 103 | NA | NA | NA |
a
Calculated as follows: (titer on receptor-expressing cells/titer on Vero cells) × 100%. NA, HSV-2 can use an endogenous receptor to enter B78H1 cells, and therefore the effect of expressed receptors for HSV-2 entry is difficult to quantify precisely on this cell line.