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. 2016 Sep 29;90(20):9305–9316. doi: 10.1128/JVI.00661-16

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Copyright © 2016 Surtees et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — The effect of HSP70/HSC70 inhibitors VER and PIF on HAZV replication. (A) Cytotoxicity of VER and PIF in SW13 cells was assessed by MTT assay after 24 h of incubation of SW13 cells with VER and PIF at several different concentrations in the absence of HAZV. Cytotoxicity levels are presented relative to 0.4% DMSO results. (B) The effect on HAZV replication of treating A549 cells with VER and PIF was determined by plaque assay, which revealed a reduction in HAZV titers at subcytotoxic PIF and VER concentrations. The statistical significance of decreased virus multiplication using PIF and VER in relation to DMSO-only controls was assessed using paired Student's t tests, and significance is shown with an asterisk (* [P < 0.05]). (C) Western blot analysis of HAZV N protein and GAPDH levels within infected cells following PIF and VER treatment at subcytotoxic concentrations. (D) HAZV N protein levels quantified from Western blot analyses performed in three experiments.