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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Adv Exp Med Biol. 2016;854:161–167. doi: 10.1007/978-3-319-17121-0_22

Figure 22.1. Hsp90 is required for GRK1 and PDE function.

Figure 22.1

(A) GRK1 requires Hsp90 for maturation. R135L rhodopsin mutant is hyperphosphorylated by functional GRK1 leading to arrestin binding and endocytosis. Hsp90 inhibitors prevent Hsp90 mediated GRK1 folding, leading to GRK1 degradation and loss of R135L hyperphosphrylation. (B) PDE needs Hsp90 and its co-chaperone AIPL1 for maturation. Hsp90 inhibition blocks the Hsp90-AIPL1 interaction, resulting in PDE degradation.