Figure 4.

Plots of observed glucose concentrations (open circles), population model predictions (dotted line), and individual model predictions (solid line) for the Cpss–full glucose profile PKPD model.

Notes: Each row represents the data for an individual subject and each column represents a different dose level, with placebo on the extreme left and increasing doses of 2.5, 5, 10, and 20 mg in the subsequent columns.

Abbreviations: PKPD, pharmacokinetic/pharmacodynamic; Cpss, steady-state glibenclamide concentration.