Table 1.
Demographic characteristics and clinical data for subjects (n=1091).
| HC | SZ | SZR | PBP | PBPR | Statistic | p value | |
|---|---|---|---|---|---|---|---|
| Subjects (N) | 200 | 225 | 201 | 234 | 231 | ||
| Mean age (years) (SD) | 37.53 (12.33) | 34.29 (12.17) | 44.19 (15.07) | 35.60 (12.55) | 41.19 (15.66) | F(4,1086)=19.2 | P<2.5e-15 |
| Sex (male/female) | 100/100 | 153/72 | 67/134 | 93/141 | 81/150 | χ2(4)=72.87 | P<5.6e-15 |
| Baltimore | 21 | 75 | 56 | 62 | 58 | - | - |
| Boston | 26 | 8 | 8 | 5 | 8 | - | - |
| Chicago | 36 | 22 | 25 | 44 | 51 | - | - |
| Dallas | 33 | 16 | 13 | 19 | 17 | - | - |
| Detroit | 29 | 30 | 27 | 26 | 17 | - | - |
| Hartford | 55 | 74 | 72 | 78 | 80 | - | - |
| Site effects | - | - | - | - | - | χ2(20)=93.65 | P<1.6e-11 |
| Mean epochs (SD) | 107.09 (35.14) | 119.9 (37.5) | 115.24 (37.63) | 112.32 (36.17) | 110.36 (34.38) | F(4,1086)=3.9 | P<0.004 |
| PANSS-positive Range Mean (SD) |
- | 7–34 16.15 (5.87) |
- | 7–38 14.4 (5.52) |
- | - | - |
| PANSS-negatives Range Mean (SD) |
- | 7–33 15.7 (5.51) |
- | 7–30 13.13 (4.7) |
- | - | - |
| PANSS-general Range Mean (SD) |
- | 16–56 30.95 (8.45) |
- | 16–57 30.23 (8.44) |
- | - | - |
| SBS Range Mean (SD) |
- | 4–9 7.69 (1.25) |
- | 0–7 2.46 (1.82) |
- | - | - |
| Cluster A & B personality disorder | 2.5% | 0% | 10% | 0% | 10% | - | - |
| Unaffected relatives | - | - | 47% | - | 45% | - | - |
| Schizoaffective disordera | 0% | 13.7% | 0% | 29.5% | 0% | ||
| Caucasian | 100 | 95 | 113 | 141 | 167 | ||
| African-American | 59 | 99 | 68 | 57 | 35 | ||
| Hispanic | 18 | 14 | 18 | 21 | 18 | ||
| Asian | 10 | 2 | 2 | 3 | 2 | ||
| American Indian | 3 | 0 | 0 | 0 | 0 | ||
| Mixed | 10 | 15 | 6 | 12 | 9 |
a
Schizoaffective disorder Probands with schizoaffective disorder depressed and manic subtype diagnoses were classified as SZ and PBP respectively. HC, healthy control; SZ, schizophrenia; SZR, first-degree relative of schizophrenia proband, PBP, psychotic bipolar disorder; PBPR, first degree relative of psychotic bipolar disorder proband; SD, Standard Deviation; PANSS, Positive and Negative Syndrome Scale; SBS Schizo-Bipolar Scale