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. 2014 Jan 21;2:1–10. doi: 10.2147/HP.S51812

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© 2014 Rovida et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Niche properties and distribution of hematopoietic stem and progenitor cell subsets. Top triangles: decrease or increase of environmental concentrations of stem/progenitor cell-extrinsic factors regulating the balance between stem cell maintenance and clonal expansion. Bottom triangles: nutrient supply to the different niche environments and metabolism in stem/progenitor cell subsets.

Abbreviations: HSCs, hematopoietic stem cells; LT, long-term; ST, short-term; HPCs, hematopoietic progenitor cells; MPPs, multipotent progenitor cell.