Figure 7.

Effects of oxidized low-density lipoproteins on cell morphology under normoxia.

Notes: Macrophages were incubated for 72 hours with 200 μg/mL of low-density lipoproteins under normoxia (21% oxygen). After incubation, the cells were fixed and processed for analysis by transmission electron microscopy. (A) A damaged and vesicularized cell incubated for 72 hours under normoxia in the presence of myeloperoxidase-modified low-density lipoproteins (magnification 6,200×). (B) A damaged cell incubated during 72 hours in the presence of copper sulfate-oxidized low-density lipoproteins. (1) Enlargement of Area 1 circled in (A) (magnification 30,000×). (2) Enlargement of Area 2 circled in (A) (magnification 15,000×).

Abbreviations: LD, lipid droplets; N, nucleus; PM, plasma membrane.