Table 1.
Proteins of iron metabolism regulated by HIF
| Proteins | Functions |
|---|---|
| HIF-1 dependent | |
| Transferrin | Iron transport |
| Transferrin receptor 1 | Iron uptake |
| Ceruloplasmin | Iron oxidation |
| Ferrochelatase | Heme synthesis |
| Furin | Regulation of iron homeostasis |
| Heme oxygenase | Heme catabolism |
| Matriptase2 | Regulation of iron homeostasis |
| HIF-2 dependent | |
| DMT1 | Iron uptake |
| DcytB | Iron reduction |
| Epo | Erythropoiesis |
| Ferroportin | Iron export |
| Frataxin | Assembly of iron sulfur-cluster |
Abbreviations: DMT1, divalent metal transporter; Epo, erythropoietin; HIF, hypoxia inducible factors.