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. 2015 Aug 7;7(6):1045–1057. doi: 10.1080/19420862.2015.1076600

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© 2015 Taylor & Francis Group, LLC

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Figure 2. — HSC scores of antibody sequences. (A) The HSC scores of human (279 sequences), humanized (61), chimeric (32), and murine (513) antibodies are distinct. In general, scores for light chains are higher than those for heavy chains. Plots illustrate HSC distributions with the upper and lower quartiles as a box, the median as a thick center line, 1.5 times the interquartile range as whiskers, and outliers as circles. (B and C) Visualization of HSC scores within a Fab, where the higher the HSC score is, the more blue. (B) Murine antibody (aL2, 1I3G) with median murine HSC score of 79.4. (C) Human antibody (scFv 9004G, 2YC1) with median human HSC score of 90.7.