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Pareto optimal variants, trading off HSC score and energy at a range of mutational loads from predecessor sequences. (A) anti-CD30 (AC10); (B) anti-EGFR (Ab 225); (C) trastuzumab; (D) bevacizumab; (E) alemtuzumab. All humanized designs generated have energies that are better than or only marginally higher than the predecessor sequences.
