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. 2016 Sep 30;11(9):e0163680. doi: 10.1371/journal.pone.0163680

Fig 6. Schematic summary of dILP2-5 signaling effects on diapause.

Fig 6

(A) dILP2-5 signaling enhancement, obtained either through IPCs sensitization (NaChBac expression) or dilp2-5 over-expression (within IPCs or in other endocrine tissues, corpus allatum, corpus cardium and fat bodies) propels ovarian development even under diapause-inducing conditions (low temperature, 12°C, and short photoperiod). (B) Impairment of dILP2-5 signaling through Ork1 expression within IPCs, insulin signaling mutants (both dilp, InR and chico mutants), IPCs ablation, dilp2-5-RNAi, or over-expressing the dILPs inhibitor Imp-L2, consolidates diapause preventing further ovarian maturation.