Table 1. Cochran-Armitage test for trend for drug withdrawals and precautions.
| AUC score bins | ~0.1 | ~0.2 | ~0.3 | ~0.4 | ~0.5 | ~0.6 | ~0.7 | ~0.8 | ~0.9 | ~1.0 | Sum. | P a |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Withdrawn Drugs | ||||||||||||
| Total | 1 | 4 | 7 | 13 | 30 | 34 | 39 | 16 | 6 | 4 | 154 | <0.001 |
| UN or EMA | 1 | 3 | 7 | 11 | 26 | 31 | 34 | 15 | 4 | 2 | 134 | 0.001 |
| UN or DrugBank | 1 | 3 | 5 | 5 | 25 | 26 | 28 | 12 | 5 | 3 | 113 | <0.001 |
| EMA or DrugBank. | 1 | 4 | 3 | 11 | 16 | 14 | 26 | 8 | 5 | 3 | 91 | 0.001 |
| UN | 1 | 2 | 5 | 3 | 21 | 23 | 23 | 11 | 3 | 1 | 93 | 0.053 |
| EMA | 0 | 1 | 2 | 8 | 6 | 8 | 12 | 4 | 1 | 1 | 43 | 0.001 |
| DrugBank | 1 | 3 | 1 | 3 | 10 | 6 | 14 | 4 | 4 | 2 | 48 | 0.007 |
| No. of Precautionary Drugs | ||||||||||||
| Beers criteria | 0 | 1 | 6 | 7 | 16 | 25 | 25 | 6 | 3 | 1 | 90 | <0.001 |
| FDA pharmacogenomics | 0 | 0 | 6 | 11 | 17 | 32 | 19 | 7 | 3 | 1 | 96 | <0.001 |
| No. of Total Study Drugs | 5 | 14 | 34 | 68 | 144 | 217 | 234 | 167 | 88 | 70 | 1041 |
aP-values by Cochran-Armitage test for trend. Abbreviations: AUC, Area under the drug-wise deleteriousness-score curve; UN, the United Nations; EMA, the European Medicines Agency; FDA, the United States Food and Drug Administration