Table 1. MntC and mAB 305-78-7 amino acid residues involved in the formation of the binding interface.
All MntC residues that are listed in the table (left column) are located within 4 Å of either heavy or light chain residues of the antibody (shown in the right column). The residues were identified using Accelrys DS Visualizer 4.5. MntC residues forming hydrogen bonds with the antibody are H234, K254, D256, K272. MntC residue E247 forms a salt bridge with the antibody residue K58 on the heavy chain.
| MntC Residues | Fab residues |
|---|---|
| K228 | Light chain, S27f |
| H234 | Heavy chain, D27 |
| V237 | Heavy chain, Y57 |
| K243 | Heavy chain, Y57 |
| E247 | Heavy chain, Y57 |
| Heavy chain, K58 | |
| S250 | Heavy chain, Y100 |
| E251 | Heavy chain, Y100 |
| E252 | Light chain, Y27d |
| T253 | Light chain, Y27d |
| K254 | Heavy chain, G99 |
| Heavy chain, Y100 | |
| Light chain, Y27d | |
| Light chain, Y32 | |
| Light chain, Y92 | |
| Light chain, S93 | |
| K255 | Heavy chain, Y100 |
| D256 | Heavy chain, Y50 |
| Heavy chain, G99 | |
| Heavy chain, Y100 | |
| Light chain, Y94 | |
| I257 | Heavy chain, Y50 |
| Heavy chain, Y56 | |
| F258 | Heavy chain, N52 |
| Heavy chain, S53 | |
| Heavy chain, S54 | |
| Heavy chain, Y56 | |
| Heavy chain, D97 | |
| G259 | Heavy chain, S54 |
| Heavy chain, Y56 | |
| E260 | Heavy chain, Y56 |
| K272 | Heavy chain, S54 |