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. 2016 Sep 30;12(9):e1006355. doi: 10.1371/journal.pgen.1006355

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© 2016 Wu et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) Breeding strategy to generate constitutive Mtu1 knockout mice. ATG indicates the start codon. (B) Total number of wild-type (Mtu1^+/+), heterozygous (Mtu1^+/-) and homozygous (Mtu1^-/-) animals obtained from parental Mtu1^+/- mice. (C) Morphology of Mtu1^+/+, Mtu1^+/- and Mtu1^-/- embryos at stage E9. Bar = 5 mm. Note that the development of Mtu1^-/- embryos was severely delayed. (D) Genotyping analysis of embryos. DNA fragments corresponding to the wild-type (WT) allele and deleted (KO) allele are shown. Asterisks indicate the genotypes of the embryos shown in (C). (E) Blood vessel networks in embryos shown in (C) were examined by immunostaining against PECAM-1.