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. 2016 Sep 30;11(9):e0164009. doi: 10.1371/journal.pone.0164009

Table 1. Individual characteristics according to variables in patients with hemophilia A from 1998 to 2008.

Variables Rehabilitation users (n = 321) Rehabilitation non-users (n = 456) P
Gender 0.296
    Male 311 (96.9%) 435 (95.4%)
    Female 10 (3.1%) 21 (4.6%)
Mean age (years) 0.002
    < 20 109 (34.0%) 215 (47.2%)
    20 to < 36 108 (33.6%) 137 (30.0%)
    36 to < 51 71 (22.1%) 71 (15.6%)
    ≥ 51 33 (10.3%) 33 (7.2%)
Mean insured amount per month <0.001
    < USD 528 183 (57.0%) 320 (70.2%)
    ≥ USD 528 138 (43.0%) 136 (29.8%)
Urbanization level* 0.266
    1 (most urbanized) 96 (29.9%) 123 (27.0%)
    2 108 (33.6%) 133 (29.2%)
    3 52 (16.2%) 102 (22.4%)
    4 41 (12.8%) 66 (14.4%)
    5 7 (2.2%) 6 (1.3%)
    6 10 (3.1%) 19 (4.2%)
    7 (least urbanized) 7 (2.2%) 7 (1.5%)
Musculoskeletal or neurological surgical procedures <0.001
    Yes 141 (43.9%) 67 (14.7%)
    No 180 (56.1%) 389 (85.3%)
Total costs (USD) for clotting factor VIII concentrates 545,762 ± 602,351 341,582 ± 445,437 <0.001
Total costs (USD) for bypass agents 53,641 ± 273,364 380 ± 5,622 <0.001
Mean cost (USD) for rehabilitation 843 (3–38402) 0

USD, United States dollar.

*The urbanization level of each patient was determined according to the median value of urbanization level in the database from 1998 to 2008.