Table 2. Published Case Reports of Radiotherapy for the Treatment of Chylothorax Secondary to Malignancy.
CLL = chronic lymphocytic leukemia; HL = Hodgkin's lymphoma; HN = head and neck; LN = lymph node; NHL = non-Hodgkin's lymphoma
Study | Age (sex) | Diagnosis | Effusion | Radiotherapy Dose (# = fractions) | Outcome |
Ampil [11] | 74 F | CLL | Left | 1,000 cGy in 5# to the mediastinum | Resolved at 6 weeks |
Cigarral [12] | 58 M | Metastatic prostate cancer pelvic LN, retroperitoneum, mediastinum, HN | Bilateral | 3,000 cGy in 10# | Patient condition deteriorated and radiation was not completed |
Daly [13] | 42 M | Stage IV NHL, mediastinal mass | Left | 3,000 cGy in 10# | Resolution after 6 fractions. No re-accumulation at 3 months. |
Gerstein [10] | 45 F | Stage IVA follicular lymphoma, celiac trunk | Bilateral Right > Left | 1,500 cGy in 10# with a boost of 540 cGy in 3# | Improvement after 5 fractions; resolution at the end of radiotherapy. No re-accumulation at 16 months. |
Heaton [14] | 70 F | Anaplastic carcinoma, mediastinum | Right | 4,000 cGy | Resolution at the end of radiotherapy. No re-accumulation at 2.5 years. |
Janjetovic [15] | 28 M | Stage IIA HL, mediastinal mass | Left | 3,000 cGy | Significant regression at the end of radiotherapy. |
Little [16] | 66 M | Metastatic prostate cancer, lungs, supraclavicular LN | Left | 4,400 cGy to the mediastinum and left supraclavicular LN | Resolved and controlled at 5 months. |
Scholz [17] | 65 M | CLL | Right | 2,400 cGy to the mediastinum and thoracic duct | Persisted at 8 weeks. |
Swenson [18] | 28 M | Lymphosarcoma, abdomen | Bilateral | 3,150 rads in 25# | Resolution at the end of radiotherapy |
48 M | Lymphosarcoma, abdomen | Left | 3,850 rads in 25# | Resolution mid-way through radiotherapy. No re-accumulation at 3 months | |
Tan [19] | 53 M | Stage IV NHL with concurrent tuberculosis | Bilateral | Mediastinal radiation | Persisted for 57 days |
Van De Voorde [20] | 63 F | Stage IIE follicular lymphoma, celiac trunk | Right | 400 cGy in 2# | Resolution at the end of radiotherapy. No re-accumulation at 6 months |
Zimhony [21] | 81 F | CLL | Left | 2,100 cGy to the mediastinum | Persisted |