Skip to main content
. 2016 Apr 29;7(20):28765–28782. doi: 10.18632/oncotarget.9117

Figure 4. XAV939 inhibits YAP-dependent transformation by a S127 phosphorylation-independent mechanism.

Figure 4

A.-C. Western blot analysis A., TEAD reporter activity B. and relative mRNA expression of TEAD target genes C. in MCF10A cells stably expressing YAP-WT, YAP-S127A or YAP-S94A. D. Anchorage-independent growth of MCF10A cells stably expressing YAP-WT, YAP-S127A or HRAS-V12 and treated with XAV939, verteporfin (VP) or CTR. E. Anchorage-independent growth of MCF10A cells stably expressing YAP-WT, YAP-S127A or HRAS-V12 in the presence or absence of dnTEAD4 overexpression. Error bars indicate SD of experiments performed in triplicate. ***P≤0.001. Student t-Test.