Table 3. A674563, MLN518 and TCS359 anti-proliferative effect against FLT3 ligand stimulated MOLM13, MOLM14 and MV4-11 cell lines.
GI50(μM) | A674563 | MLN518 | TCS359 |
---|---|---|---|
MOLM-13 | 0.06 | 0.042 | 0.42 |
MOLM-13+FL(1 ng/mL) | 0.061 | 0.18 | > 10 |
MOLM-13+FL(5 ng/mL) | 0.058 | 0.26 | > 10 |
MOLM-13+FL(10 ng/mL) | 0.059 | 0.27 | > 10 |
MOLM-14 | 0.18 | 0.054 | 10–3 |
MOLM-14+FL(1 ng/mL) | 0.21 | 0.19 | > 10 |
MOLM-14+FL(5 ng/mL) | 0.19 | 0.2 | > 10 |
MOLM-14+FL(10 ng/mL) | 0.18 | 0.22 | > 10 |
MV4-11 | 0.075 | 0.046 | 0.49 |
MV4-11+FL(10 ng/mL) | 0.078 | 0.056 | 1.4 |