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. 2016 Apr 13;7(20):29306–29320. doi: 10.18632/oncotarget.8720

Figure 1. NFIB expression correlates inversely with astrocytoma grade.

Figure 1

(A) NFIB expression is higher in WHO grade II and III astrocytic gliomas (II/III) and lower in GBM. NFIB expression in patient tissue was determined by qPCR. NFIB expression also correlates inversely with astrocytic glioma grade in the independent (B) Sun [21], (C) Feije [22] and (D) French [23] microarray datasets. In the TCGA GBM dataset [26] (E) NFIB expression was highest in proneural GBM and lowest in mesenchymal GBM. NFIB expression in the proneural subtype is significantly different from all other subtypes (ANOVA P < 0.0001). (F) NFIB protein expression was highest in proneural and neural low-passage, patient-derived GBM cell lines and lowest in classical and mesenchymal lines as determined by immunoblot and (G) correlated with mRNA expression as determined by qPCR. Colour of dots corresponds to GBM subtypes in F.