Table 2. Univariate Cox regression analysis of prognostic factors influencing the survival of patients with lymph node-positive cervical cancer.
| Variable | CCSS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Year of diagnosis (continuous variable) | 0.967 | 0.953–0.982 | < 0.001 | 0.973 | 0.961–0.986 | < 0.001 |
| Race | ||||||
| Black | 1 | 1 | ||||
| White | 0.878 | 0.663–1.163 | 0.367 | 0.882 | 0.699–1.113 | 0.291 |
| Other | 0.879 | 0.610–1.268 | 0.490 | 0.951 | 0.706–1.281 | 0.740 |
| Age (years) | ||||||
| < 50 | 1 | 1 | ||||
| ≥ 50 | 1.289 | 1.079–1.540 | 0.005 | 1.803 | 1.565–2.077 | < 0.001 |
| Tumor histology | ||||||
| Squamous | 1 | 1 | ||||
| Adenocarcinoma | 1.720 | 1.412–2.096 | < 0.001 | 1.5643 | 1.393–1.937 | < 0.001 |
| Other | 1.791 | 1.416–2.267 | < 0.001 | 1.632 | 1.339–1.990 | < 0.001 |
| Grade | ||||||
| Well-differentiated | 1 | 1 | ||||
| Moderately-differentiated | 1.233 | 0.759–2.003 | 0.397 | 1.004 | 0.699–1.442 | 0.983 |
| Poorly/undifferentiated | 1.566 | 0.973–2.519 | 0.065 | 1.209 | 0.848–1.723 | 0.293 |
| FIGO stage | ||||||
| I | 1 | 1 | ||||
| II | 1.824 | 1.533–2.169 | < 0.001 | 1.834 | 1.589–2.117 | < 0.001 |
| LNR | ||||||
| 0.01–0.12 | 1 | 1 | ||||
| > 0.12 | 1.850 | 1.558–2.197 | < 0.001 | 1.830 | 1.588–2.109 | < 0.001 |
| LNR (continuous variable) | 3.495 | 2.432–5.023 | < 0.001 | 3.434 | 2.540–4.644 | < 0.001 |
| Postoperative RT | ||||||
| No | 1 | 1 | ||||
| Yes | 0.783 | 0.634–0.966 | 0.022 | 0.745 | 0.628–0.884 | 0.001 |
| Number of positive lymph nodes (continuous variable) | 1.095 | 1.069–1.122 | < 0.001 | 1.089 | 1.066–1.113 | < 0.001 |
| Number of RLNs (continuous variable) | 0.991 | 0.985–0.998 | 0.015 | 0.988 | 0.983–0.994 | < 0.001 |
Abbreviations: CCSS, cervical cancer-related survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; RT, radiotherapy; FIGO, International Federation of Gynecology and Obstetrics; LNR, lymph node ratio; RLNs, removed lymph nodes.