Figure 6. In vivo anti-tumor potency of B7-H3Bi-armed ATC in mouse lung cancer metastasis model.
SCID/Beige mice were inoculated intravenously with 2 ×106 A549-luc cells. On day 0, day1 and day3, tumor-bearing mice were administrated i.v. with 2 ×107 B7-H3Bi-armed ATC or unarmed ATC respectively (each group contains 5 mice). Tumor growth was monitored using an in vivo imaging system A. Bioluminescence images of 3 representative mice of each group were shown on indicated day. B. Images were analyzed using Living Image software and tumor values represented as total flux measurements in photons/second, mean values of tumor growth curves were shown. C. Survival curves of mice engrafted with A549-luc cells receiving B7-H3Bi-armed ATC or unarmed ATC were shown. *P< 0.05, **P < 0.01, ***P < 0.001, B7-H3Bi-armed ATC was compared with unarmed ATC under similar conditions.