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. 2016 Apr 18;7(20):29664–29676. doi: 10.18632/oncotarget.8819

Figure 5. The RNA chaperone La assists structural changes of the Bcl2 translation start site in vitro.

Figure 5

A. The RNA chaperone domain (RCD) of La is mutated in LaΔRCD [21). RNA-binding motifs: LAM, RRM1, and RRM2. Scheme representing the RNA chaperone assay and the predicted structure of the Bcl2 RNA used as molecular beacon (Bcl2-MB). B. Differences in RNA chaperone activity given in relative fluorescence units (arbitrary units = AU) in the presence of 300 nM La wildtype protein (LaWT) compared to the molecular beacon (Bcl2-MB) alone or in presence of 300 nM recombinant La protein with mutated RNA chaperone domain (LaΔRCD). P value < 0.001 (three asterisks), n = 6.

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