Table 2. Univariate and multivariate Cox regression analysis of RFS in each dataset.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI of HR | P-value | HR | 95% CI of HR | P-value | ||
| Discovery dataset, n=121 | |||||||
| lncRNA signature | High risk vs. Low risk | 45.728 | 6.241-335.1 | 1.69e-04 | 31.259 | 4.158-235.021 | 8.25e-04 |
| Age | >65 vs. <=65 | 2.876 | 1.44-5.744 | 2.75e-03 | 2.771 | 1.314-5.845 | 0.007 |
| Gender | Male vs. Female | 1.623 | 0.818-3.222 | 0.166 | 1.23 | 0.505-2.995 | 0.649 |
| Stage | II vs. I | 4.761 | 2.397-9.455 | 8.31e-06 | 2.243 | 1.102-4.566 | 0.026 |
| Smoking status | Yes vs. No | 1.574 | 0.789-3.14 | 0.198 | 1.099 | 0.43-2.809 | 0.843 |
| Testing dataset, n=105 | |||||||
| lncRNA signature | High risk vs. Low risk | 11.02 | 3.346-36.3 | 7.96e-05 | 11.5 | 3.344-39.57 | 1.06e-04 |
| Age | >65 vs. <=65 | 1.015 | 0.439-2.348 | 0.972 | 1.213 | 0.516-2.856 | 0.658 |
| Gender | Male vs. Female | 1.02 | 0.509-2.044 | 0.955 | 0.481 | 0.165-1.402 | 0.18 |
| Stage | II vs. I | 2.52 | 1.234-5.145 | 0.011 | 1.147 | 0.546-2.408 | 0.717 |
| Smoking status | Yes vs. No | 1.197 | 0.597-2.399 | 0.612 | 1.695 | 0.585-4.913 | 0.331 |
| Okayama dataset, n=226 | |||||||
| lncRNA signature | High risk vs. Low risk | 20.66 | 7.5-56.91 | 4.7e-09 | 17.619 | 6.266-49.543 | 5.36e-08 |
| Age | >65 vs. <=65 | 1.801 | 1.72-3.025 | 0.026 | 1.949 | 1.145-3.315 | 0.014 |
| Gender | Male vs. Female | 1.268 | 0.783-2.055 | 0.335 | 0.905 | 0.471-1.738 | 0.765 |
| Stage | II vs. I | 3.37 | 2.066-5.497 | 1.13e-06 | 1.609 | 0.969-2.67 | 0.066 |
| Smoking status | Yes vs. No | 1.324 | 0.816-2.148 | 0.256 | 1.09 | 0.565-2.102 | 0.797 |
| Der dataset, n=124 | |||||||
| lncRNA signature | High risk vs. Low risk | 1.829 | 1.074-3.115 | 0.026 | 1.938 | 1.135-3.31 | 0.015 |
| Age | >65 vs. <=65 | 1.327 | 0.756-2.328 | 0.324 | 1.397 | 0.788-2.477 | 0.252 |
| Gender | Male vs. Female | 1.267 | 0.761-2.109 | 0.364 | 1.312 | 0.778-2.213 | 0.308 |
| Stage | II vs. I | 2.64 | 1.559-4.469 | 3.02e-04 | 2.746 | 1.615-4.67 | 1.92e-04 |
| Smoking status | Yes vs. No | 1.219 | 0.628-2.366 | 0.559 | 0.968 | 0.49-1.914 | 0.926 |
| Botling dataset, n=53 | |||||||
| lncRNA signature | High risk vs. Low risk | ç1.86 | 0.939-3.685 | 0.075 | 1.997 | 0.976-4.084 | 0.058 |
| Age | >65 vs. <=65 | 1.231 | 0.653-2.321 | 0.521 | 1.118 | 0.58-2.155 | 0.74 |
| Gender | Male vs. Female | 1.123 | 0.59-2.138 | 0.725 | 1.152 | 0.552-2.404 | 0.706 |
| Stage | I | 1.000 (reference) | 1.000 (reference) | ||||
| II | 1.823 | 0.796-4.176 | 0.156 | 2.074 | 0.878-4.898 | 0.096 | |
| III | 2.338 | 1.027-5.322 | 0.043 | 2.624 | 1.066-6.459 | 0.036 | |
| IV | 4.61 | 0.588-36.143 | 0.146 | 3.866 | 0.46-32.479 | 0.213 | |
Abbreviations: HR, hazard ratio; CI, confidence interval.