Table 2.

Grading of local tolerability symptoms

Gradea	Burning/stinging	Pruritus	Erythema
0 (none)	No stinging/burning	No pruritus	No detectable erythema; skin of normal color
1 (mild)	Slight warm, tingling sensation; not really bothersome	Occasional, slight itching/scratching	Slight pinkness present
2 (moderate)	Definite warm, tingling sensation that is somewhat bothersome	Constant or intermittent itching/scratching that is not disturbing sleep	Definite redness, easily recognized
3 (severe)	Hot, tingling/stinging sensation that has caused definite discomfort	Bothersome itching/scratching that is disturbing sleep	Intense redness

^aGrades of 0.5, 1.5, and 2.5 were allowed as midpoints between the definite grades of 0, 1, 2, and 3