Table 1.
DBD Phosphorylation as a Degradation Signal for Nuclear Receptors
| NR | Phosphorylation Dependent |
Proteasome Dependent |
||
|---|---|---|---|---|
| Full | ΔLBD | Full | ΔLBD | |
| Degradation | ||||
| FXR | + | + | + | + |
| CAR | − | + | − | + |
| VDR | − | + | − | + |
| TRα | − | + | − | + |
| Rev-erbα | − | + | − | + |
| Stabilization | ||||
| RORα | + | − | − | − |
| HNF4α | + | + (Degrade) | − | + (Degrade) |
| PPARα | + | − | − | − |
| None | ||||
| RXRα | − | − | − | − |
| ERα | − | − | − | − |
| SF1 | − | − | − | − |
The effects of phosphomimetic mutation on nuclear receptors were summarized. The marks mean as follows: +, degradation; −, no degradation; + (Degrade), degradation.