Figure 3.

Fat depots in ovariectomized female mice are decreased by E₂ but not by EDC. Wild-type ovariectomized female mice were placed on control chow (A, C, E, G, and I) or Western diet (B, D, F, H, and J), treated for 12 weeks with control vehicle (Veh), E₂, empty dendrimer control (Dend), or an estrogen equivalent amount of EDC, and multiple fat depots were quantified. The depots were intrascapular BAT (n = 8–10 for control diet and n = 17–21 for high-fat diet) (A and B), inguinal WAT (n = 8–13) (C and D), mesenteric WAT (n = 8–13) (E and F), uterine WAT (n = 8–10 for control diet and n = 16–21 for high-fat diet) (G and H), and gonadal WAT (n = 6–10) (I and J). Values are mean ± SEM; *, P < .05 vs vehicle control.