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Pancreatic insulin+ area is correlated with the percentage of β-cells in mitosis. Fetal pancreatic sections from CONs (open circles, n = 7), IUGR (closed circles, n = 6), and IUGR+AA (gray squares, n = 9) were immunostained for insulin to define β-cells and pHH3 to define cells in mitosis. A linear association was found between the insulin+ area (y-axis) and the percentage of β-cells in mitosis (x-axis) by linear regression for all fetuses combined (P < .01).
