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Serum E2 and LH levels for female and male ERαKO mice. E2 levels were elevated in both female (A) and male (B) ERαKO and WT mice treated with E2. However, LH was suppressed by E2 in female (C) and male (D) WT littermate control, but not in ERαKO females (C) and males (D). Different letters denote significant group differences within each sex (P < .05).
