Table 1.
Examples of hPXR agonists.
| Compound | Description (indication, drug class, etc.) | Reference |
|---|---|---|
| 12-Ketolithocholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| 3-Keto-7α,12α-dihydroxy-5α-cholanic acid | Bile salt found in sea lamprey | Krasowski et al. (2005)24 |
| 5α-Cyprinol 27-sulfate | Bile salt found in zebrafish | Krasowski et al. (2005)24 |
| 5β-Pregnane-3,20-dione | Steroid hormone | Jones et al. (2000)25 |
| 5β-Scymnol 27-sulfate | Bile salt found in cartilaginous fish | Krasowski et al. (2005)24 |
| 7,12-Diketolithocholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| 7-Ketodeoxycholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| 7-Ketolithocholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| Carbemazepine | Epilepsy | Luo et al. (2002)26 |
| Cholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| Clotrimazole | Anti-fungal | Xie et al. (2000)27; Luo et al. (2002)26; Xie et al. (2003)28; Jones et al. (2000)25 |
| Corticosterone | Glucocorticoid | Jones et al. (2000)25 |
| Cyproterone acetate | Antineoplastic (prostate); androgen disorders, steroidal anti-androgen | Jones et al. (2000)25 |
| Deoxycholic acid | Bile salt found in rabbit | Krasowski et al. (2005)24 |
| Dexamethasone | Glucocorticoid | Xie et al. (2000)27; Luo et al. (2002)26 |
| Dexamethasone-t-butyl acetate | Glucocorticoid | Synold et al. (2001)29; Luo et al. (2002)26 |
| Estradiol | Steroid hormone | Luo et al. (2002)26 |
| Glycolithocholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| Glycolithocholic acid 3-sulfate | Bile salt found in humans | Krasowski et al. (2005)24 |
| Hyodeoxycholic acid | Bile salt found in many mammals | Krasowski et al. (2005)24 |
| Hyperforin | St. John׳s Wort; herbal supplement commonly used for depression | Luo et al. (2002)26 |
| Lithocholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| Lithocholic acid 3-sulfate | Bile salt found in humans | Krasowski et al. (2005)24 |
| Lithocholic acid acetate | Bile salt found in humans | Krasowski et al. (2005)24 |
| Lithocholic acid acetate methyl ester | Bile salt found in humans | Krasowski et al. (2005)24 |
| Mifepristone (RU486) | Pregnancy termination, steroidal antiprogesterone | Xie et al. (2000)27; Jones et al. (2000)25 |
| Nonylphenol | Anthropogenic environmental estrogen | Mota et al. (2011)30 |
| Paclitaxel (Taxol) | Anti-neoplastic | Synold et al. (2001)29; Luo et al. (2002)26 |
| Petromyzonol 24-sulfate | Bile salt found in sea lamprey | Krasowski et al. (2005)24 |
| Phenobarbital | Epilepsy | Jones et al. (2000)25; Luo et al., (2002)26 |
| Pheytoin | Seizure disorders | Luo et al. (2002)26 |
| Piperine | Component of the spice, black pepper | Wang et al. (2013)31 |
| Pregnenolone | Steroid hormone | Jones et al. (2000)25 |
| Progesterone | Steroid hormone | Jones et al. (2000)25 |
| Rifampicin | A component of the first line anti-tuberculosis therapy | Jones et al. (2000)25; Synold et al. (2001)29; Xie et al. (2000)27; Xie et al. (2003)28; Luo et al. (2002)26 |
| Ritonavir | HIV, protease inhibitor | Luo et al. (2002)26 |
| Spironolactone | Diuretic, steroidal anti-mineralocorticoid | Jones et al. (2000)25 |
| SR12813 | Dyslipidemia, HMG-CoA inhibitor | Jones et al. (2000)25; Synold et al. (2001)29 |
| Sulfadimidine | Antibiotic, sulfonamide | Luo et al. (2002)26 |
| Sulfinpyrazone | Gout | Luo et al. (2002)26 |
| Taurochenodeoxycholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| Taurohyodeoxycholic acid | Bile salt found in many mammals | Krasowski et al. (2005)24 |
| Taurolithocholic acid | Bile salt found in humans | Krasowski et al. (2005)24 |
| Trans-nonachlor (Chlordane) | Pesticide | Jones et al. (2000)25 |
| Troglitazone | Diabetes (withdrawn), thiazolidinedione | Jones et al. (2000)25 |
| Troleandomycin | Antibiotic, macrolide | Luo et al. (2002)26 |
| α-Muricholic acid | Bile salt found in rat | Krasowski et al. (2005)24 |