Fig. 1.

Representative bioenergetic profiles from CD14+ monocytes, platelets, skeletal muscle isolated mitochondria, cardiac isolated mitochondria, and permeabilized skeletal muscle fibers from one animal. Respiration is measured as oxygen consumption rate (pmol/min/250,000 cells [monocytes], pmol/min/mg protein [platelets], pmol/min/5 µg mitochondrial protein [left vastus and cardiac tissues]), and pmol/min/mg dry weight [permeabilized fibers]. In isolated mitochondrial preparations, complex II (CII) respiration was measured using succinate and rotenone as substrates. Ama=antimycin-A, c=cytochrome c, D=adenosine diphosphate, F=carbonyl-cyanide-p-trifluoromethoxyphenylhydrazone, G=glutamate, M=malate, O=oligomycin, P=pyruvate, R=rotenone, S=succinate, U=uncoupler (FCCP).