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. 2016 Sep 30;8:101. doi: 10.1186/s13073-016-0352-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Network topological analysis of genetically regulated transcripts and metabotypes. a Summary of adipose transcripts and metabotypes associated with genomic regions using joint eQTL and mQTL mapping. b Mapping of mQTL-responsive metabolites and eQTL-responsive genes on an adipose-specific metabolic network. c Biologically relevant relationships between mQTL-responsive metabolites and eQTL-responsive transcripts highlighted by ranking of shortest path lengths across the metabolic network between gene–metabolite pairs (Additional file 3: Table S5). d Null distribution of average shortest path lengths obtained after 10,000 permutations consisting of a random selection of 20 metabolites and 73 reactions. The Asns enzyme has two catalytic sites for two reactions, which are identified as Asns-A and Asns-B in this figure