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. 2016 Oct 1;15:139. doi: 10.1186/s12933-016-0456-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Confidence interval (CI) bars indicated by FDA guideline. Shown are five examples of hazard ratios (HR) and the upper limit of the 95 % CI of a development plan and regulatory consequences of each outcome. S superiority, NI non-inferiority, I inferiority, UP underpowered