Table 1.
Patient Diagnosis, H. pylori status and SLFN5 Histologic Scores
| Histologic Diagnosisa | N | Stromal H Score Median (P25,P75) | Categorized Stromal H Score b N(%) | Age Mean (±SD) | Gender (%Male) | ||
|---|---|---|---|---|---|---|---|
| Negative | Weak positive | Moderate positive | |||||
| Normal | 41 | 1.25 (0.17, 4.07) | 37 (90.24) | 4 (9.76) | 0 (0) | 42.5 (18.8) | 51.2 |
| NAG | 26 | 2.53 (0.33, 6.33) | 21 (80.77) | 5 (19.23) | 0 (0) | 44.2 (12.3) | 46.1 |
| MAG | 49 | 0.84 (0, 3.00) | 40 (81.63) | 9 (18.37) | 0 (0) | 48.5 (12.6) | 38.8 |
| CIM | 44 | 5.73 (1.00, 24.64) | 25 (56.82) | 18 (40.91) | 1 (2.27) | 53.1 (10.5) | 45.4 |
| CIM→GC | 6 | 50.68 (6.5, 92.31) | 2 (33.33) | 4 (66.67) | 0 (0) | 62.0 (6.6) | 50 |
| CIM→Not GC | 38 | 2.53 (1.00, 14.4) | 23 (60.53) | 14 (36.84) | 1 (2.63) | 51.7 (10.4) | 44.7 |
| IIM | 54 | 5.11 (0.13, 34.25) | 32 (59.26) | 20 (37.04) | 2 (3.7) | 58.3 (12.8) | 50 |
| IIM→GC *** | 19 | 40.00 (15.67, 70.0) | 3 (15.79) | 14 (73.68) | 2 (10.53) | 66.5 (13.6) | 63.2 |
| IIM→Not GC | 35 | 1.14 (0, 7.58) | 29 (82.86) | 6 (17.14) | 0 (0) | 53.8 (9.9) | 42.9 |
| Total IM | 98 | 5.43 (0.7, 25.29) | 57 (58.04) | 38 (38.97) | 3 (2.98) | 55.9 (12.1) | 48 |
| IM→GC *** | 25 | 40.18 (15.67, 70.0) | 5 (24.56) | 18 (70.17) | 2 (5.26) | 65.4 (12.4) | 60 |
| IM→Not GC | 73 | 2.00 (0.4, 11.60) | 52 (71.69) | 20 (26.99) | 1 (1.31) | 52.7 (10.1) | 43.8 |
| GC | 67 | 1.38 (0, 9.67) | 51 (76.12) | 16 (23.88) | 0 (0) | 72.6 (11.0) | 61.2 |
| Intestinal | 41 | 8.3 (0, 10.38) | 31 (75.6) | 10 (24.39) | 0 (0) | 72.97 (10.15) | 56.1 |
| Diffuse | 25 | 7.46 (0, 9.76) | 19 (76) | 6 (24) | 0 (0) | 70.6 (12.43) | 17 (68) |
| Mixed | 1 | 2.38 | 1 (100) | 0 (0) | 0 (0) | 66 | 1 (100) |
Normal= Normal gastric mucosa not infected by H. pylori; NAG= Non-atrophic gastritis; MAG= multi-focal atrophic gastritis; CIM= Complete Intestinal Metaplasia; CIM→GC= CIM that progressed to gastric cancer; CIM→No GC= CIM that did not progress to gastric cancer; IIM= Incomplete Intestinal Metaplasia; IIM→GC= IIM that progressed to gastric cancer; IIM→No GC= IIM that did not progress to gastric cancer; IM= Intestinal Metaplasia; IM→GC Intestinal Metaplasia (CIM+IIM) that progressed to Gastric Cancer; IM→No GC= Intestinal Metaplasia that did not progress to gastric cancer; GC= gastric cancer.
Categorized Stromal score H was compared between IIM→GC vs IIM→No GC (Mann-Whitney p<0.0001 ***) and between IM→GC vs IM→No GC (Mann-Whitney p<0.0001 *). The Kruskal-Wallis test was performed to compare groups of Normal, NAG, MAG, CIM, IIM and GC, yielding significant results (p=0.0033)