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Tumor associated macrophage (TAM) – recruitment, transformation and activity. Due to secretion of different factors (CCL-2, M-CSF) from the tumor stroma, monocytes accumulate at the tumor microenvironment (TME). Due to the primarily immunosupressive nature of TME, these monocytes differentiate into M2 phenotype. M2 macrophages assist tumor survival and metastasis as well as downregulates immune response at the TME by secretion of different cytokines.
