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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Apr 1;8(6):891–908. doi: 10.1002/wnan.1406

Figure 6.

Figure 6

Proposed mechanism for Cellax intracellular internalization. Cellax adsorbs albumin in circulation and accumulated within the tumor interstitium through the leaky vasculature of the tumor. SPARC produced in the tumor microenvironment binds to the surface albumin on the Cellax nanoparticles and thus traps the particles in the tumor. Cellax is internalized via a clathrin-mediated mechanism and finally ends up in the endo-lysosomal compartment, where the polymer is broken down and the drug is released. Adapted from Hoang et al., Biomaterials. 2015.