Table 1.
MIC valuesa (in μg/mL) determined for all compounds and for the control antibacterial agent (AMK) against various S. aureus strains.
| Cpd # | A | B | C | D | E | F | G | H | I | J | K | L | M | N |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ebselen | 2 | 3.9 | 2 | 0.5 | ≤0.25 | 2 | 7.8 | 2 | 1 | 0.5 | 2 | 3.9 | 1 | 2 |
| 2a | 7.8 | 3.9 | 3.9 | 0.5 | 2 | 7.8 | 7.8 | 3.9 | 2 | 2 | 7.8 | 3.9 | 2 | 3.9 |
| 2b | 3.9 | 2 | 3.9 | 1 | 3.9 | 2 | 3.9 | 2 | 3.9 | 1 | 3.9 | 3.9 | 2 | 2 |
| 2c | 3.9 | 2 | 2 | 1 | 1 | 1 | 3.9 | 2 | 1 | 1 | 3.9 | 3.9 | 1 | 2 |
| 2d | 2 | 2 | 2 | 0.5 | 3.9 | 2 | 3.9 | 2 | 2 | 1 | 3.9 | 3.9 | 2 | 2 |
| 2e | 2 | 2 | ≤0.25 | ≤0.25 | ≤0.25 | 1 | 2 | ≤0.25 | 0.5 | 0.5 | 1 | 1 | 0.5 | ≤0.25 |
| 2f | 7.8 | 3.9 | 1 | 1 | 3.9 | 2 | 7.8 | 2 | 2 | 2 | 7.8 | 7.8 | 2 | 2 |
| 2g | 7.8 | 7.8 | 3.9 | 2 | 7.8 | 3.9 | 7.8 | 3.9 | 3.9 | 3.9 | 7.8 | 3.9 | 3.9 | 3.9 |
| 2h | 3.9 | 0.5 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | 1 | ≤0.25 | ≤0.25 | ≤0.25 | 0.5 | ≤0.25 | ≤0.25 | ≤0.25 |
| 2j | 7.8 | 7.8 | 3.9 | 1 | 7.8 | 7.8 | 7.8 | 3.9 | 3.9 | 3.9 | 15.6 | 7.8 | 7.8 | 7.8 |
| 2k | 1 | 0.5 | ≤0.25 | ≤0.25 | ≤0.25 | 1 | 2 | 0.5 | ≤0.25 | 0.5 | 2 | 2 | ≤0.25 | 1 |
| 2l | >125 | 2 | 0.5 | 0.5 | 1 | 0.5 | 2 | 2 | 0.5 | 1 | 2 | 15.6 | 0.5 | 2 |
| 2m | 7.8 | 7.8 | 7.8 | 3.9 | 15.6 | 7.8 | 15.6 | 3.9 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 |
| 3a | 7.8 | 3.9 | 3.9 | 1 | 0.5 | 2 | 3.9 | 2 | 2 | 2 | 3.9 | 7.8 | 1 | 0.5 |
| 3b | 7.8 | 3.9 | 3.9 | 2 | 2 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 7.8 | 2 | 0.5 |
| 3c | 1 | 1 | 1 | 0.5 | 0.5 | 1 | 1 | 1 | 0.5 | 1 | 1 | 2 | 0.5 | ≤0.25 |
| 3d | 62.5 | 3.9 | 3.9 | 2 | 0.25 | 1 | 15.6 | 3.9 | 1 | 2 | 15.6 | 3.9 | 1 | 0.5 |
| 3e | 7.8 | 125 | 15.6 | >125 | 7.8 | 15.6 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 3.9 |
| 3f | 3.9 | >125 | 3.9 | >125 | 3.9 | 7.8 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 7.8 | 3.9 | 2 |
| 3g | 15.6 | 15.6 | 15.6 | 3.9 | 7.8 | 15.6 | 15.6 | 7.8 | 7.8 | 15.6 | 15.6 | 15.6 | 7.8 | 7.8 |
| 3h | 2 | 3.9 | 1 | 1 | 0.5 | 2 | 2 | 3.9 | 1 | 1 | 2 | 3.9 | 1 | 1 |
| 3i | 3.9 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 3.9 | 1 | 0.5 |
| 3j | 3.9 | 2 | 2 | 1 | 0.5 | 2 | 3.9 | 2 | 2 | 2 | 3.9 | 3.9 | 2 | 0.5 |
| 3k | 7.8 | 3.9 | 2 | 3.9 | 2 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 3,9 | 3,9 | 3.9 | 2 |
| 3l | 7.8 | 3.9 | 3.8 | 2 | 2 | 3.9 | 7.8 | 2 | 3.9 | 3.9 | 2 | 3.9 | 3.9 | 2 |
| 3m | 7.8 | 3.9 | 3.9 | 1 | 2 | 3.9 | 2 | 2 | 2 | 3.9 | 2 | 3.9 | 1 | 0.5 |
| 3n | 2 | >125 | 2 | >125 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 2 | 3.9 | 2 | 1 |
| 4e | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| 4f | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| 4n | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| AMK | 2 | ≤0.25 | 62.5 | 31.3 | 31.3 | 3.9 | 62.5 | 2 | 2 | 7.8 | 31.3 | 31.3 | 3.9 | 31.3 |
| Cpd # | O | P | Q | R | S | T | U | V | W | X | Y | Z | AA | AB |
| Ebselen | 1 | 1 | 1 | 7.8 | 1 | 3.9 | ≤0.25 | 1 | 1 | 0.5 | 2 | 2 | 3.9 | 3.9 |
| 2a | 3.9 | 3.9 | 2 | 7.8 | 3.9 | 3.9 | ≤0.25 | 3.9 | 2 | 7.8 | 3.9 | 3.9 | 3.9 | 3.9 |
| 2b | 3.9 | 2 | 2 | 3.9 | 3.9 | 3.9 | ≤0.25 | 3.9 | 2 | 2 | 2 | 3.9 | 2 | 2 |
| 2c | 2 | 2 | 1 | 3.9 | 3.9 | 3.9 | ≤0.25 | 1 | 2 | 1 | 2 | 2 | 3.9 | 2 |
| 2d | 3.9 | 2 | 2 | 3.9 | 2 | 2 | ≤0.25 | 3.9 | 2 | 2 | 7.8 | 3.9 | 3.9 | 3.9 |
| 2e | 0.5 | 1 | 1 | 2 | 0.5 | 1 | ≤0.25 | ≤0.25 | 0.5 | ≤0.25 | 0.5 | 1 | 2 | 1 |
| 2f | 7.8 | 3.9 | 3.9 | 7.8 | 3.9 | 3.9 | 0.5 | 3.9 | 2 | 2 | 2 | 3.9 | 3.9 | 7.8 |
| 2g | 3.9 | 7.8 | 7.8 | 7.8 | 3.9 | 3.9 | 0.5 | 3.9 | >125 | 3.9 | 3.9 | 7.8 | 3.9 | 7.8 |
| 2h | 0.5 | 0.5 | 0.5 | 1 | ≤0.25 | 0.5 | ≤0.25 | ≤0.25 | 1 | ≤0.25 | 0.5 | 0.5 | ≤0.25 | ≤0.25 |
| 2j | 7.8 | 7.8 | 3.9 | 7.8 | 7.8 | 7.8 | ≤0.25 | 3.9 | 3.9 | 7.8 | 3.9 | 7.8 | 7.8 | 7.8 |
| 2k | 1 | 0.5 | ≤0.25 | 2 | 1 | 2 | ≤0.25 | 1 | 0.5 | ≤0.25 | 0.5 | 0.5 | ≤0.25 | 2 |
| 2l | 0.5 | 0.5 | 2 | 2 | 1 | 2 | ≤0.25 | 1 | 1 | 0.5 | 0.5 | 2 | 2 | 2 |
| 2m | 7.8 | 7.8 | 7.8 | 15.6 | 7.8 | 15.6 | 2 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 15.6 |
| 3a | 2 | 2 | 2 | 2 | 3.9 | 2 | ≤0.25 | 2 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 |
| 3b | 3.9 | 2 | 2 | 3.9 | 3.9 | 3.9 | ≤0.25 | 3.9 | 3.9 | 3.9 | 7.8 | 7.8 | 3.9 | 7.8 |
| 3c | 1 | 1 | 1 | 1 | 1 | 1 | ≤0.25 | 1 | 1 | 1 | 2 | 3.9 | 2 | 3.9 |
| 3d | 1 | 1 | 2 | 3.9 | 3.9 | 2 | 1 | 1 | 3.9 | 1 | 3.9 | 7.8 | 7.8 | 7.8 |
| 3e | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 2 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 |
| 3f | 3.9 | 3.9 | 7.8 | 3.9 | 7.8 | 3.9 | 1 | 3.9 | 7.8 | 3.9 | 7.8 | 7.8 | 7.8 | 7.8 |
| 3g | 15.6 | 15.6 | 15.6 | 15.6 | 7.8 | 15.6 | 2 | 15.6 | 15.6 | 15.6 | 15.6 | 15.6 | 15.6 | 15.6 |
| 3h | 2 | 1 | 1 | 1 | 2 | 1 | ≤0.25 | 1 | 2 | 1 | 2 | 2 | 2 | 2 |
| 3i | 1 | 1 | 1 | 2 | 2 | 2 | 0.5 | 1 | 3.9 | 2 | 3.9 | 2 | 2 | 3.9 |
| 3j | 2 | 2 | 2 | 2 | 2 | 2 | ≤0.25 | 2 | 3.9 | 2 | 2 | 3.9 | 2 | 3.9 |
| 3k | 3,9 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 0.5 | 3.9 | 7.8 | 3.9 | 3.9 | 3.9 | 3.9 | 7.8 |
| 3l | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 0.5 | 7.8 | 7.8 | 3.9 | 7.8 | 7.8 | 7.8 | 7.8 |
| 3m | 2 | 2 | 3.9 | 2 | 3.9 | 2 | 0.5 | 1 | 3.9 | 3.9 | 3.9 | 7.8 | 15.6 | 7.8 |
| 3n | 2 | 2 | 3.9 | 0.5 | 2 | 2 | 1 | 2 | 7.8 | 3.9 | 7.8 | 7.8 | 7.8 | 7.8 |
| 4e | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| 4f | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| 4n | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | 125 | >125 | >125 | >125 | >125 |
| AMK | 15.6 | 15.6 | 31.3 | 31.3 | 15.6 | 0.5 | 7.8 | 31.3 | 7.8 | 31.3 | 62.5 | 62.5 | 62.5 | 62.5 |
Bacterial strains: A = S. aureus ATCC 6538, B = S. aureus ATCC 25923, C = S. aureus ATCC 29213, D = S. aureus ATCC 33591, E = MRSA1, F = MRSA2, G = MRSA BRS3, H = MRSA C1, I = MRSA C2, J = MRSA C7, K = MRSA C14, L = MRSA C16, M = MRSA C19, N = MRSA G1, O = MRSA G6, P = MRSA G12, Q = MRSA G14, R = MRSA MRSA NRS4, S = MRSA NRS51, T = MRSA NRS77, U = MRSA S14, V = MRSA S17, W = MRSA S22, X = MRSA S24, Y = MRSA USA100, Z = MRSA USA200, AA = MRSA USA300, AB = MRSA USA600.