Table 2.
MIC valuesa (in μg/mL) determined for all compounds and for the control antibacterial agent (AMK) against various non-S. aureus bacterial strains.
| Cpd # | AC | AD | AE | AF | AG | AH | AI |
|---|---|---|---|---|---|---|---|
| Ebselen | 0.25 | 0.5 | ≤0.25 | 0.5 | 1 | 1 | 7.8 |
| 2a | 1 | 31.3 | 15.6 | 7.8 | 1 | 2 | 3.9 |
| 2b | 2 | 62.5 | >125 | 31.3 | 2 | 2 | 1 |
| 2c | 1 | 62.5 | >125 | 31.3 | 0.5 | 1 | 3.9 |
| 2d | 2 | 7.8 | 15.6 | 7.8 | 2 | 2 | 0.5 |
| 2e | 0.25 | 15.6 | 62.5 | 15.6 | ≤0.25 | 0.5 | 0.5 |
| 2f | 2 | 7.8 | <125 | 7.8 | 2 | 3.9 | 3.9 |
| 2g | 3.9 | 15.6 | >125 | 15.6 | 7.8 | 3.9 | 3.9 |
| 2h | 0.25 | >125 | >125 | 3.9 | ≤0.25 | 1 | 1 |
| 2j | 3.9 | 15.6 | 15.6 | 15.6 | 3.9 | 7.8 | 3.9 |
| 2k | 0.25 | 2 | 7.8 | 3.9 | 0.5 | 2 | 2 |
| 2l | 0.25 | >125 | >125 | >125 | 0.5 | 2 | 1 |
| 2m | 3.9 | >125 | >125 | >125 | 7.8 | 7.8 | 7.8 |
| 3a | 3.9 | 7.8 | >125 | 15.6 | 1 | 3.9 | 2 |
| 3b | 2 | >125 | >125 | 7.8 | 2 | 3.9 | 2 |
| 3c | 1 | >125 | >125 | 2 | 0.5 | 1 | 2 |
| 3d | 0.25 | >125 | >125 | 3.9 | 1 | 15.6 | 7.8 |
| 3e | 7.8 | 7.8 | 15.6 | 7.8 | 3.9 | >125 | 3.9 |
| 3f | 3.9 | 7.8 | 15.6 | 7.8 | 2 | >125 | 3.9 |
| 3g | 15.6 | 15.6 | 125 | 7.8 | 3.9 | 3.9 | 3.9 |
| 3h | 1 | 31.3 | >125 | 2 | 1 | 1 | 2 |
| 3i | 2 | >125 | >125 | >125 | 1 | 3.9 | 2 |
| 3j | 2 | 15.6 | >125 | 15.6 | 0.5 | 2 | 3.9 |
| 3k | 2 | >125 | >125 | >125 | 2 | 3.9 | 2 |
| 3l | 2 | >125 | >125 | >125 | 2 | 3.9 | 2 |
| 3m | 2 | >125 | >125 | 7.8 | 2 | 3.9 | 7.8 |
| 3n | 3.9 | 15.6 | 15.6 | 15.6 | 1 | >125 | 3.9 |
| 4e | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| 4f | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| 4n | >125 | >125 | >125 | >125 | >125 | >125 | >125 |
| AMK | 15.6 | 125 | >125 | 125 | 62.5 | 3.9 | ≤0.25 |
Bacterial strains: AC = S. epidermidis ATCC 35984, AD = E. faecalis ATCC 29212, AE = E. faecalis ATCC 49533, AF = E. faecium BM4105-RF, AG = VRE, AH = L. monocytogenes ATCC 19115, AI = M. smegmatis MC2-155.