Table 1.
Patient and tumor characteristics of 289 patients with MPNST
| N (%) of column total | Overall | Sporadic | NF1-associated | RT-associated | P Valuea (P Value)b |
|---|---|---|---|---|---|
| 289(100) | 115(39.8) | 148(51.2) | 26(8.9) | ||
| Median age, years (range) | 37(1–81) | 43(5–81) | 33(1–75) | 52(20–77) | <0.001 (<0.001) |
| Median tumor size, cm (range) | 8.0(1.0–35.0) | 6.0(1.0–32.0) | 10(2.5–35.0) | 6.0(1.5–15.0) | <0.001 (<0.001) |
| Sex | |||||
| Female | 134(46.4) | 52(45.2) | 68(45.9) | 14(53.8) | 0.720 (0.906) |
| Male | 155(53.6) | 63(54.8) | 80(54.1) | 12(46.2) | |
| Disease at primary diagnosis | |||||
| Localized | 274(94.8) | 105(91.3) | 143(96.6) | 26(100.0) | 0.071 (0.065) |
| Metastatic | 15(5.2) | 10(8.7) | 5(3.4) | 0(0.0) | |
| Location | |||||
| Head/neck | 43(14.9) | 23(20.0) | 13(8.8) | 7(26.9) | 0.008c (0.211) |
| Cervical nerve root | 15(5.2) | 4(3.5) | 5(3.4) | 6(23.0) | |
| Cranial nerve | 13(4.5) | 8(6.9) | 4(2.7) | 1(3.8) | |
| Other nerve | 9(3.1) | 8(6.9) | 1(0.7) | 0(0.0) | |
| Nerve unknown | 6(2.1) | 3(2.6) | 3(2.0) | 0(0.0) | |
| Trunk | 157(54.3) | 54(47.0) | 85(57.4) | 18(69.2) | |
| Brachial plexus trunks/divisions | 21(7.3) | 5(4.3) | 9(6.1) | 9(34.6) | |
| Brachial plexus cords | 9(3.1) | 4(3.5) | 2(1.3) | 3(11.5) | |
| Lumbosacral nerve root | 37(12.8) | 19(16.5) | 18(12.2) | 0(0.0) | |
| Thoracic nerve root | 17(5.9) | 3(2.6) | 12(8.1) | 2(7.6) | |
| Sciatic nerve | 12(4.2) | 1(0.8) | 10(6.8) | 1(3.8) | |
| Phrenic | 4(1.4) | 1(0.8) | 3(2.0) | 0(0.0) | |
| Obturator | 4(1.4) | 0(0.0) | 4(2.7) | 0(0.0) | |
| Femoral | 6(2.7) | 2(1.7) | 3(2.0) | 1(5.9) | |
| Other nerve | 25(8.7) | 7(6.1) | 16(10.8) | 2(11.8) | |
| Nerve unknown | 20(6.9) | 12(10.4) | 8(5.4) | 0(0.0) | |
| Upper extremity | 26(8.9) | 13(11.3) | 12(8.1) | 1(3.8) | |
| Radial nerve | 4(1.4) | 2(1.7) | 2(1.3) | 0(0.0) | |
| Median nerve | 7(2.4) | 3(2.6) | 3(2.0) | 1(3.8) | |
| Ulnar nerve | 7(2.4) | 3(2.6) | 4(2.7) | 0(0.0) | |
| Other nerve | 4(1.4) | 3(2.6) | 1(0.6) | 0(0.0) | |
| Nerve unknown | 4(1.4) | 2(1.7) | 2(1.3) | 0(0.0) | |
| Lower extremity | 63(21.8) | 25(21.7) | 38(25.7) | 0(0.0) | |
| Sciatic nerve | 25(8.7) | 6(5.2) | 19(12.8) | 0(0.0) | |
| Femoral nerve | 7(2.4) | 3(2.6) | 4(1.4) | 0(0.0) | |
| Obturator nerve | 2(0.7) | 0(0.0) | 2(1.3) | 0(0.0) | |
| Tibial nerve | 9(3.1) | 5(4.3) | 4(2.7) | 0(0.0) | |
| Other nerve | 10(3.5) | 3(2.6) | 6(4.1) | 0(0.0) | |
| Nerve unknown | 10(3.5) | 8(6.9) | 2(1.3) | 0(0.0) | |
| Depth d | |||||
| Deep | 272(94.1) | 104(90.4) | 143(96.6) | 25(96.2) | 0.096 (0.037) |
| Superficial | 17(5.9) | 11(9.6) | 5(3.4) | 1(3.8) | |
| Histologic subclassification | |||||
| MPNST, not further classified | 258(89.3) | 94(81.7) | 140(94.6) | 24(92.3) | 0.001 (<0.001) |
| Epithelioid | 20(6.9) | 17(14.8) | 2(1.4) | 1(3.8) | |
| Triton tumor | 11(3.8) | 4(3.5) | 6(4.1) | 1(3.8) | |
| Grade | |||||
| Low-intermediate | 12(4.2) | 6(5.2) | 5(3.4) | 1(3.8) | 0.791 (0.480) |
| High (or not evaluated) | 277(95.8) | 109(94.8) | 143(96.6) | 25(96.2) | |
Percentages may not add to 100 due to rounding. Bold indicates statistical significance of p < 0.05
a
Three group comparison between sporadic, NF1-associated, and RT-associated characteristics
b
Two group comparison between sporadic and NF1-associated characteristics
c
Comparisons between four major anatomical locations (head/neck, trunk, upper extremity, lower extremity)
d
Tumors with extension through or seated below the superficial fascia were considered deep.