Table 2.
Treatment characteristics of 274 patients with localized disease at presentation
| N (%) column total | Overall | Sporadic | NF1- associated |
RT- associated |
P Valuea (P Value)b |
|---|---|---|---|---|---|
| 274 (100) | 105 (38.3) | 143 (52.2) | 26 (9.5) | ||
| Surgery | |||||
| Yes | 259 (94.5) | 102 (97.1) | 133 (93.0) | 24 (92.3) | 0.321 (0.248) |
| No | 15 (5.5) | 3 (2.9) | 10 (7.0) | 2 (92.3) | |
| Resection Margins (n = 259) | |||||
| R0 | 145 (60.0) | 66 (64.7) | 70 (52.6) | 9 (37.5) | <0.001c (<0.001) |
| R1 | 54 (20.8) | 13 (12.7) | 36 (27.1) | 5 (20.8) | |
| R2 | 23 (8.9) | 7 (6.9) | 9 (6.8) | 7 (29.2) | |
| Unknown | 37 (14.3) | 16 (15.7) | 18 (13.5) | 3 (12.5) | |
| Therapy-surgically resected (n = 259) | 0.312d (0.590) | ||||
| Surgery alone | 75(27.3) | 31(29.5) | 36(25.2) | 8(30.8) | |
| Chemotherapy alone + surgery | 45(16.4) | 19(18.1) | 19(13.3) | 7(26.9) | |
| Neoadjuvant | 18(6.6) | 5(4.7) | 10(6.9) | 3(11.5) | |
| Adjuvant | 26(9.5) | 14(13.3) | 9(6.3) | 3(11.5) | |
| Both neo-/adjuvant | 1(0.3) | 0(0.0) | 0(0.0) | 1(3.8) | |
| Radiation alone + surgery | 75(27.4) | 29(27.6) | 39(27.3) | 7(26.9) | |
| Neoadjuvant | 11(4.0) | 3(2.8) | 8(5.9) | 0(0.0) | |
| Adjuvant | 63(22.9) | 26(24.8) | 31(21.7) | 6(23.1) | |
| Other (IORT) | 1(0.3) | 0(0.0) | 0(0.0) | 1(3.8) | |
| Chemoradiotherapy + surgery | 64(24.4) | 23(21.9) | 39(27.3) | 2(7.7) | |
| Neoadjuvant | 22(8.0) | 8(7.6) | 14(9.8) | 0(0.0) | |
| Adjuvant | 29(10.6) | 14(13.3) | 14(9.8) | 1(3.8) | |
| Other combination | 13(4.7) | 1(1.0) | 11(7.7) | 1(3.8) | |
| Therapy-no surgical resection (n = 15) | 0.240 (0.296) | ||||
| Palliative chemotherapy | 9 (3.3) | 3 (2.9) | 5 (3.5) | 1 (3.8) | |
| Palliative radiotherapy | 1 (0.3) | 0 (0.0) | 1 (0.6) | 0 (0.0) | |
| Palliative chemoradiotherapy | 5 (1.8) | 0 (0.0) | 4 (2.7) | 1 (3.8) | |
| Local recurrence | 98 (35.7) | 33 (31.4) | 51 (35.7) | 14 (53.8) | 0.102 (0.486) |
| Distant metastasis | 120 (43.8) | 47 (44.8) | 65 (45.5) | 8 (30.8) | 0.369 (0.914) |
Abbreviations: IORT, intraoperative radiotherapy. Percentages may not add to 100 due to rounding. Bold indicates statistical significance of p < 0.05
a
Three group comparison between sporadic, NF1-associated, and RT-associated characteristics
b
Two group comparison between sporadic and NF1-associated characteristics
c
Comparisons exclude unknown resection margins
d
Overall comparison between surgery alone, chemotherapy + surgery, radiation + surgery, or chemoradiotherapy + surgery.